The evil Vaglass organization attacks the city's giant energy source known as the Enetron. Ryuji, the Blue Buster, and Yoko, the Yellow Buster, fight back their forces, but when they summon the giant robot known as a Megazord, another Go-Buster appears, Hiromu Sakurada, the Red Buster.

When both Yoko and Hiromu are taken out of action due to their Weakpoints, Ryuji must work on his own when the Enetron suffers a leak.

The Go-Busters infiltrate a hospital where Vaglass has taken hostages in their attempt to acquire Enetron.

Chief Kuroki plans to increase the military potential of the Buster Machines while Enter creates a new Metaloid right in front of the Go-Busters, something that they realize is out of character for him.

Ryuji and Yoko escort an Enetron tank across the city when TireRoid is sent after it. However, something happens to Ryuji when he overheats, making him turn against his own team.

Hiromu has difficulties in forming Go-BusterOh for the first time with Ryuji and Yoko, and Enter sends the SprayRoid in a plan to bring the damaged MegaBuster Gamma (formerly CutterBuster) back online to destroy the Go-Busters from the inside out.

A rookie mechanic takes over maintenance of the Go-Buster Ace, making Hiromu feel unsure if he is ready. The Denshaloid attacks, and there is a problem when preparing Ace to combat the new Vaglass Megazord...

Ryuji is reunited with his old high school classmate Kazuya who has become one of the Go-Busters' engineers, while Enter tries to infiltrate the Go-Busters' base of operations to steal a new Buster Machine's blueprints.

After Yoko and Usada get in a fight, Usada gets kidnapped by amateur thugs who request 2000 tons of Enetron. Needing Enetron to power a new breed of MegaZord, Enter gets involved, hoping to take the Enetron and finish off the Go-Busters.

Hiromu's older sister Rika confronts him on his joining the Go-Busters.

Gorisaki develops an alarm to alert Ryuji when he is nearing the target body temperature for his Weakpoint to activate, and Enter uses this to his advantage.

With the threat of a MegaZord, the Go-Busters must work undercover taking care of the Hong Kong actress Angie Sue and they discover that she and Yoko look very much alike.

Taking a day off from their missions, the Go-Busters and their Buddyroids head to a local amusement park and zoo. However, they discover Enter wandering about and planning, and to make matters worse, Commander Kuroki suddenly left the base without warning.

Hiromu and Ryuji must figure out a way to save Yoko from Tubaloid 2 after her Weakpoint activated at the wrong time.

Chief Kuroki tells the team that they will soon be meeting Beet Buster and his new Buddy Roid, but before any introduction can be made, the Soujikiloid attacks.

When Hiromu learns that the two new Go-Busters originated from Hyper Space, he challenges Jin to a duel, suspicious of their motives.

Ryuji is surprised when Masato calls for an Enetron transfer station to be shut down, leaving him as the only available Go-Buster to battle a Vaglass Megazord when Go-Buster Oh cannot be formed.

To stop Drilloid, Hiromu, Ryuji, and Masato descend down into the depths of the Earth in their Megazords while Yoko and Jay keep watch on the surface.

With J's presence as a member of the Go-Busters, Nick starts to feel that he is not good enough as he does not have a specialty like his fellow Buddyloids. On his time out in the city, Enter and Spannerloid capture him.

Finding the Energy Management Center base's air conditioner on the fritz, Hiromu and Yoko find Ryuji overheating before he loses consciousness. After the others get him to the medical ward, having met Masato earlier, Gorisaki frets when told by the man that Ryuji's inclusive medical checkup says he might die the next time he goes berserk. Hiromu and Yoko come up with a plan to save Ryuji before they are deployed to the Nakaya district where they face off against Dumbelloid before they find themselves exercising against their will, allowing the Metaloid to escape. Soon after, after playing the age card, Hiromu convinces Kuroki to make Morishita the new Blue Buster, much to Ryuji's dismay.

When a prank call brings the Go-Busters and Enter and his new Metaloid Keyloid to a hotel, they all meet Messiah's newest avatar in the real world: Escape.

On Yoko's birthday, she learns her mother was a Megazord pilot and a colleague of Masato's. However, the Metaloid Jishakuloid attacks, sticking Hiromu, Nick, Ryuji, and Jay together, leaving Masato to have Yoko test a risky prototype armor.

Hiromu is called in by his old high school friends to help out when they need another person to join their performance troupe at the city's summer festival. The appearance of Wataameloid puts Hiromu in a sticky situation when he has to abandon his old friends to assist his teammates.

Masato's ghost stories during Obon scare Yoko, and the arrival of Rousokuloid and his dream altering powers only make things worse.