When there is a spate of random shootings in Shinjuku, a sister of one of the victims wants Ryo to catch the killer and bring him to justice. But Ryo can tell that there is much more than justice that his client is interested in.

Ryo's client is a daughter of a known scientist who developed a deadly microbe that could render humanity sterile. His client wants him to protect her at all costs while she develops a vaccine, but should she be captured, she wants him to kill her before terrorists can extract the knowledge of the microbe from her.

A boxer is killed over a fight for a championship title, and Ryo must deal with the victim's rival obsessed with glory. At the same time, he must deal with the boxer's girlfriend, whose pain is not only in her heart, but also in her body as well.

Ryo's partner Hideyuki is frantic over the disappearance of her sister Kaori as a spate of abductions of women have swept Shinjuku. As he is trying to find his partner's sister, he comes across a man who is not who he seems to be. Together, they must find the secret into the kidnappings.

Hideyuki is killed on Kaori's birthday as he refuses to do a request for the head of a powerful crime syndicate. Ryo must avenge his death.

As Kaori takes over as Ryo's new partner, Ryo is called upon to solve a string of incidents involving actress Yumiko Sato. As he delves deep into the mystery, he comes across a powerful adversary, as well as a client who may have a deadly death wish.

Ryo's client is a man who wants to fake his own death to be free from a powerful politician so he could be reunited with his daughter. The man admits to be spineless but he is more than meets the eye. Ryo must masquerade as the hitman not only to save his client, but to ensure that the men working for the politician do not bother his client again.

A Police detective named Saeko Nogami hires Ryo to obtain a crown containing a microchip which has stolen top secret plans inside. While Ryo agrees to do his job, he awaits his ""payment"" which leaves Kaori confused as to how this payment would be applied.

Ryo must protect a lovely casino dealer as she prepares for a showdown with a rival syndicate in order to win her freedom. Meanwhile, Ryo is pitted against a powerful gambler who exploits Ryo's weaknesses to their fullest extent.

Ryo is tricked into doing bodyguard work for the daughter of a Yakuza Boss being stalked by a biker team. Ryo realizes that the daughter is the leader of a female gang at her school, and finds there is much more than what the Yakuza boss is requesting.

Ryo is requested to assist a female thief in stealing a black tulip from a fraudulent psychic. Kaori finds out that the psychic's butler has a crush on her and decides he may be helpful in obtaining the plant.

Ryo must protect a woman and a young boy from another country from being abducted by foreign agents. Kaori soon discovers that the young boy's actions and demeanor are exactly as Ryo's.

Ryo is assigned to protect young pop idol Nagisa from an unknown fanatic, however he is more interested in her female manager. However, it turns out that Nagisa is very attracted to Ryo and Ryo decides to use this to his advantage to ensure her safety.

Saeko enlists the help of Ryo to solve the dissappearances of beautiful women in Shinjuku. The stakes are even higher when Kaori, mistaken for a beautiful woman, is also kidnapped. Ryo encounters the mastermind of the scheme, a supposedly beautiful woman who may not be who she seems to be.

Ryo is requested to protect the daughter of a dead tycoon who claims that Ryo had saved her from kidnappers once before. As Ryo tries to find out who is trying to kill her, her stepmother comes up as a very likely suspect, but is being controlled by someone else.

An old friend of Kaori's is being stalked by strange characters who are after strange looking watches that were slipped into her bag. Despite Kaori's efforts to keep her away from Ryo, Kaori is kidnapped by the men and Ryo and her friend must rescue her.

Ryo is recruited by a famous fashion designer's assistant after her designs were stolen by her boss.

Corrupt businessman, an incompetent assassin, and a old lady complicates Ryo's job to protect a beautiful psychic.

Ryo is asked to investigate threats made to women attending an audition for a film featuring a handsome actor. One of these ladies attending this audition is hoping to reunite with her long-lost father, the director of the movie.

Ryo is hired to defend a jungle princess from members of her own tribe intent in breaking their isolation from the modern world.

When Ryo finds himself in a hotel with Saeko, he is forced to accept a job to protect a former newspaper magnate from hitman that he hired himself.

While snooping around a lingerie show, Ryo comes across a woman who stole a beautiful diamond necklace from a wealthy young man. The woman asks Ryo to be her lover, but Ryo is aware that there is more to her story than meets the eye.

A bride literally falls into Ryo's lap and along with it, some goons hired by the jilted groom. While trying to sneak up on her during the middle of the night, Ryo gets stung by an experimental, but deadly bee. The bride does have the antidote, but as Kaori finds out, it has "terrible" side effects, most notably showing the feminine side of City Hunter.

In order to find out who is targeting a nurse who is due to be the recipient of a large inheritance, Ryo breaks his foot and ends up in the same hospital the nurse is staying. While Ryo must not tell the nurse that she is being targeted, he also finds out she does not have enough experience being a nurse.

Ryo teams up with a beautiful American agent to find out who is smuggling tanks from Japan.

After helping to protect a young girl named Akemi from some ruthless thugs, she insists that Ryo is her future husband and that they were destined to be married. While Ryo is able to get away, Akemi decides to enlist his help as her bodyguard to protect her from an unknown assailant named Kaijin X. In fact, the marriage story is a farce so that Akemi can leave her career as a young model.

Ryo discovers that Akemi is being targeted by a professional assassin named the Silver Fox. Ryo must protect her while helping her get out of a career in entertainment.

Humiliated in their last encounter, the Silver Fox pledges revenge against Ryo. He issues a formal challenge to Ryo by saying that he has targeted Kaori, Ryo's "lover" for death and that Ryo must protect her from his attacks. When Kaori confronts Ryo about this, Ryo acts non-commital to the challenge. After an incident in which Ryo falls for a trick set up by the Silver fox, he informs Kaori that she is no longer to be his assistant.

Kaori seeks hiding from the Silver Fox with Umibozu. She then catches Ryo babbling to Saeko babbling about how Kaori is just crazy about him and how he does not really care about her and that Kaori is unfit to be Ryo's partner (even though Ryo really cares for Kaori). With that revelation, she seeks training in creating boobytraps from Umibozu and seeks to take matters in her own hands by challenging the Silver Fox herself.

While doing research for a hardcore mystery novel, the publishing company sends a bodyguard to guard Azusa while she completes her book. Her adventures include visiting friendly Yakuza, an interview with Umibozu, and a plot to kill the friendly Yakuza boss. What she does not realize is that the City Hunter is the bodyguard hired to protect her.

After stealing a supposed forgery of a masterpiece, the daughter of a famed artist requests Ryo's services to help her expose her father's former protege as a fraud.

Ryo and Kaori travel to an isolated tropical island to help a young girl protect the ecologically sensitive island from thugs looking to harvest its valuable mineral resources.

While shopping for dates, Ryo comes across a young woman who decides to parade him in front of her country-living father in order to convince her father that she is seeing someone and wants to stay in the city. When her father notices that Ryo has a gun, Ryo tries to pretend to be a police detective, steals a police car, and promptly gets involved in trying to break up a hostage situation during a bank robbery.

Ryo and Saeko's date is interrupted by the discovery of a known fraud, and the subsequent traffic stop by a beautiful traffic cop. Meanwhile, Kaori finds that she was ripped off into buying a fake designer fur coat. The traffic cop then decides to help Ryo find the fraudster, whom is also the suspect Saeko is after.

Ryo is hired to protect Princess Alma, an apparently bratty young but smart girl, as well as her servant, the beautiful Salina. When Ryo initially refuses to do the job, Princess Alma offers to give him his very own personal "harem" in their home nation. But Ryo is enchanted by Salina, but is unable to touch not only out of fear for losing the harem, but because Salina possesses a strange aura that prevents Ryo from touching her. Kaori discovers the truth about Alma and Salina, that they had switched identities in order to throw Ryo off. But when Kaori and the real servant plant an idea that Salina (who is really Alma) is really a man, the real Princess Alma gets upset and runs away, realizing that she has fallen in love with Ryo.

Kaori tries to convince Ryo to find Salina (who is really Princess Alma). But when the real Salina is kidnapped by the perpetrators, Ryo, still unaware of the identity switch, must save her from the trap that the perpetrators have planned, all this while protecting the real Princess Alma.

Ryo is requested to find out who has targeted Kumi, a popular female wrestler. At first Ryo believes her "rival" may be responsible but learns that an unknown party is trying to manipulate Kumi.

Suffering from a toothache, Ryo reluctantly visits a dental clinic and has his cavity addressed by the dentist Sayuri. But at the same time, thieves are trying to bust into Sayuri's practice hoping to recover a fake tooth with a special microchip containing classified plans.

Ryo meets Shoko, a young girl who believes money is everything and is better than love. While Ryo tries to turn Shoko's attitude around, he has to contend with three men attempting to court her on behalf of a friendly Yakuza group.

Umibozu asks Ryo to take care of a young American girl named Kathleen Heywood. However, Ryo realizes that Kathleen is actually out to kill Umibozu in revenge for her father's death. The Arrival of known mercenary Dandy Jack complicates matters, and Ryo realizes that he may be the one who is manipulating Kathleen.

Despite suffering numerous injuries, Umibozu disappears to take on Dandy Jack, who was responsible for the death of his former partner who was Kathleen's father. Kathleen goes back to Dandy Jack's chateau, not knowing that she is being used in Dandy Jack's revenge against Umibozu. Once at Dandy Jack's chateau, Dandy Jack spots Umibozu and creates a scenario for a showdown between Umibozu and Kathleen.

An airliner is hijacked and all of the women are being held captive. After assisting in dealing with the hijackers, Ryo makes off with Misa Williams, unaware that she is the daughter of the leader of the opposition in the Pamela Republic. Saeko, hired to guard Misa by General Jimetil, ruler of the Pamela Republic, gives chase along with Kaori. After intercepting Ryo and Misa at a bathhouse where Ryo has taken care of two men trying to kidnap Misa, Saeko informs them that General Jimetil has been overthrown by the opposition.

General Jimetil, formerly of the Pamela Republic, flies to Tokyo as an exile. At the same time, his personal guard tries to make a strike against Ryo in order to acquire Misa as a stake against her father. While they are unsuccessful in trying to kidnap Misa, they are able to grab Saeko. Ryo must attempt to try to save Saeko without sacrificing Misa's safety.

Kaori accepts a job to protect an old man and his vintage bottle of wine from an unscrupulous wine collector. Ryo however, refuses to take the old man as his client. So when Kaori decides to take on the job by herself, Ryo decides to lend a silent helping hand.

When two brothers make an attempt on Ryo's Life, Kaori pushes Ryo out of the way only to suffer a head injury and amnesia as a result. Ryo realizes that he himself may be responsible for Kaori's predicament, so he makes arrangements for her to start a new life outside the underworld.

Ryo decides to take on Saeko's request to assist a not-so-beautiful female police officer in training for an Olympic event. Ryo realizes the young officer is being targeted by a man with a grudge, while deciding to take the officer to get a makeover to unlock her "true beauty".

Ryo meets Yoko Fuyuno, a reporter intent in writing a story about the exploits of the City Hunter. Ryo realizes that if Yoko writes her story, his cover would be blown, so he tries many ways to convince her to not write the story, starting from the fact that he is Ryoji, Ryo's fictional younger brother. A request from Saeko to bust a drug transportation route complicates matters so Ryo goes through extreme measures to bust the route while not attracting suspicion from Yoko.

Yoko is furious about the drug bust and realizes that the City Hunter was involved. While on a search at the scene, she is accosted by members of the Unryu-Kai gang who have a grudge against Ryo and realizes this is the best opportunity to have an interview with the City Hunter.

To restore the honor of an Iga Ninja Clan, a female ninja decides to challenge Ryo, entering the duel with less then stellar skills. However, she is flanked by three ninja cohorts who plan to present a challenge to Ryo.

Ryo is requested to guard Keiichi Kashiwagi, a witness in an important court case. Ryo resists until he is given a proposal to meet Keiichi's twin sister Keiko, to which Ryo gleefully accepts. But Keiichi is in fact Keiko, disguising herself as a man in order to thwart Ryo's advances.

Ryo and Kaori protect a Rubirian Embassy worker striving not only to salvage the environment of her homeland, but also to expose a smuggling ring in which a Rubirian Embassy Environmental official is involved.

Ryo and Kaori attempt to protect a female lawyer marked for death by a corrupt developer, after an electronic databook is accidentally left in her possession.

While Ryo has his gun taken away from creditors for failing to pay his rent, he is hired by a beautiful woman who is the owner of her own large company to appear on TV with her. It turns out that this TV show talks about newlyweds as the woman waxes on about her and Ryo's supposed "Love Life". She makes this admission in order to detract potential suitors more interested in her money rather than herself. Later on, it is revealed that several of her potential suitors had been involved in unfortunate accidents and Ryo suspects a powerful executive attempting to gain control of her company through marriage.

Ryo receives a strange request from Aiko, a female private investigator, to teach her how to fire a gun. At one point, Aiko gets horribly drunk after one cocktail, slugs Ryo and steals his gun, only to find it empty of bullets. The request gets even stranger when it is revealed that she needs a gun to protect herself from unknown thugs trying to prevent her from locating a strange dog for a six-year-old girl. Finally, Aiko's uncle appears in order to convince her to give up the private investigator business but when she refuses, he is hit by a car.

Aiko's uncle is revealed to have staged his accident in order to convince his niece to quit her job as a private investigator, however it is revealed that he knows nothing about the present threats against Aiko as she searches for a particular dog. When Ryo locates the dog, he notifies Aiko who goes over to retrieve it, only to be kidnapped by robbers looking for evidence the dog may have.

Miki and Umibozu get into an argument over Miki's desire to keep a stray kitten, knowing Umibozu's fear of cats. Miki walks out on Umibozu and is then kidnapped by a wealthy suitor looking for a potential mate. Umibozu and Ryo bicker on how to save Miki and set out to do so together.

Ryo is hired to protect a female assistant of a famous French Explorer from thugs. Ryo learns that she has been unable to keep a relationship because of embarrassing situations she happens to get herself into. While this is happening, the older French Explorer takes an immediate shine to Kaori, much to the latter's excitement.

Ryo comes across a college girl who is a fan of detective movies, and tails Ryo for a chance to see some action, not knowing Ryo's lecherous tendencies. However, it turns out the college girl has been targeted for unwittingly witnessing a crime and Ryo must intervene after Kaori has been kidnapped by these same criminals.

Ryo is hired by a female weather reporter to protect her against a deranged fan.

Ryo and Kaori receive a strange request from the head of the Yamaoka family looking to retrieve his daughter, Tsubaki from the son of the rival Umino family, Kazuhiko. It appears that Tsubaki and Kazuhiko have eloped against their parent's wishes and both families want the couple broken up to preserve the rivalry. When Tsubaki manages to escape from Ryo, Kaori volunteers to go to the Umino mansion for a party where she witnesses Tsubaki crash the party with a horse to retrieve Kazuhiko. As they escape, Ryo notices a strange car following the couple.

Tsubaki and Kazuhiko attempt to flee their country to evade the wrath of their parents but are attacked by a helicopter in the process. However, they are saved by Ryo who manages to take down the helicopter in one shot. Meanwhile, Ryo investigates the rivalry between the Yamaoka and Umino families and comes across some startling information. He also uncovers evidence that a third party is also trying to break up the couple by marking them for death.

On the anniversary of the death of his friend, Robert Harrison, Ryo gets royally drunk and notices a woman watching him. This woman turns out to be Sophie Silverman, who represents an international firm of sweepers. Sophie wishes to tag along with Ryo and Kaori for a few days to witness him in his line of work. On their way to a potential job, the three are attacked by unknown assailants. After warding them off in a warehouse, Ryo finds Sophie pointing Robert Harrison's gun at him.

Sophie Silverman is revealed to be the fiance of Robert Harrison and reveals her intentions of avenging his death. After seriously wounding Ryo, Sophie kidnaps Kaori as bait for a future showdown. While Ryo recovers from his injuries, he realizes that a syndicate known as the Guiness Corporation is after Sophie and had extorted Robert to take on a job that meant certain death at the hands of Ryo Saeba. When the Guiness Corporation ambushes Sophie and Ryo, the two put aside their rivalry to repel the attackers, only to find themselves in a deadly showdown.

A plane carrying drugs and a wanted woman crashes into Ryo's apartment which forces him and Kaori to sleep on the same bed.

Kaori overhears a phone conversation between Ryo and Saeko after which she realises that she has rented her room to a detective whose motive is to arrest Ryo.

Ryo comes across a stuntwoman named Yuki who is trying to get her memory back by performing dangerous stunts. She believes Yuki is being hypnotised by someone.

Ryo is chased by the police as they think he is the underwear thief. He escapes with the help of Miyuki.

Ryo stumbles upon a pretty ghost named Ami Asaka who tells him that she was murdered by a serial killer. She hires him to protect her younger sister.

Ryo comes clean about the fact that he pretended to be Ami's fiance to get close to Mami which infuriates her. She gets a letter from Ami who asks her to trust him.

Kaori befriends an Austrian orphan, Hans Zeigfried who is a professional killer and dying from a fatal disease. Kaori is abducted by Hans' enemies.