In the year 300X, the diabolical Czar Baldy-Bald IV proclaims a hair hunt throughout his Chrome Dome Empire, forcing everyone under his rule to be as bald as him. But in the midst of the chaos emerges a rebel with a golden afro and an insane way of doing things. That man is Bobobo-bo Bo-bobo! This episode introduces Bo-bobo, along with the pink-haired Beauty (who joins along on his hair-raising adventures) and the vinegary Pickles (who is never seen again after this episode), along with several mysterious characters we'll probably meet again later.

Due to circumstances in the last episode, Bo-bobo ends up facing off against the orange star-shaped Wiggin Don Patch in a Christmas-themed Wiggin battle (involving a story about churros), but when Beauty gets abducted by a group of wig-wearing Hair Hunters, the two of them must join together to confuse the heck out of them! Weirdness regarding vegetables and joining in on the villain's date follow suit. Yet with Beauty abandoned to the Hair Hunters, she at least is saved by a mysterious white-haired boy.

Leaving behind Don Patch for the moment, Bo-bobo and Beauty first head to a Wig-Out Festival, where we discover the value of giant burger costumes and why dynamite should never play the stock market. Then, the duo encounter a hair hunter with a weird taste in underwear, considering there's a duck sticking out of the front of it!

Don Patch is ready to go out on his own and join with Bo-bobo and Beauty, but first he has to finish "Wiggin' School", where Bo-bobo isn't making his last day any easier. Then, as the trio continue their journey (and drive each other crazy), they face off against a water-logged Hair Hunter that can read minds and are forced to witness the revival (and quick abandonment) of the legendary king of the nosehairs.

Bo-bobo and Don Patch decide to throw a play in the middle of the woods where the plot becomes more bizarre with each scene. But without notice, they find themselves under siege from a strange green tentacle alien in search for a familiar boy (familiar to Beauty, anyway) and a power that leads to a very unstoppable craving for—rice soup!? But after an underwater battle and an unexpected finale, Bo-bobo finally brings the creature down—without knowing that he works for an even more foreboding opponent.

Continuing their journey to another city, Bo-bobo tries to master a new technique from a famed pasta maker and witnesses wooden spoons making...wooden spoons. But when Beauty is attacked with a "hair-loss beam" from a Hair Hunter from C-Block, our heroes must begin a new journey to save the heroine, save the day...and figure out why Don Patch's weapons are all green onions.

Crash landing inside C-Block Tower, Bo-bobo and Don Patch begin an upwards battle against the local hair hunters, while learning along the way about dental hygiene, poultry pageants, and the importance of having two video stores on top of each other. But that's before they find out their next mysterious opponent...well, has an interesting taste in head gear.

Bo-bobo finally faces off against Softon, the fourth-floor guardian who claims he's strawberry soft serve (but we know better). While he does claim to have Beauty's welfare at heart, Softon also has an unstoppable arsenal of techniques and the abilities of the goddess Blabs-a-Lot! But that's before Bo-bobo unleashed on him the enigma that is Bo-bobo World.

Finally reaching the top of C-Block Tower, our heroes face off against the windy Geha the Gale (even though Beauty's already been saved). But when Bo-bobo and Don Patch are blown away by the competition, a new challenger finally makes his presence known: Gasser, master of the "Fist of the Backwind" and the boy that has been watching Beauty all this time! (though his appearance doesn't explain why Bo-bobo turns into a leopard)

A giant wall monster emerges from out of nowhere in C-Block Tower, with the objective of capturing Gasser and stealing his "Fist of the Backwind". But Bo-bobo sees a bigger problem: how Gasser's ultimate technique is powerful enough to destroy life on Earth as we know it! And that probably explains why he and Don Patch make fun of the battle in progress...

With Gasser now a part of his team, Bo-bobo decides to teach him a few things about fighting. The first lesson: how to defeat an opponent without using his own special technique. But when that fails after a battle with a Hair Hunter, his education moves to the "Nosehair Dojo", where beating up fish and fighting old women (and one old man) are on the curriculum.

Gasser's education continues while Bo-bobo and Don Patch fend chopsticks from a thieving pencil case. But no one could expect what comes next: the mysterious appearance of a new amusement park controlled by the leader of A-Block, Jelly Jiggler. And with a friend of Bo-bobo (whom we've never seen prior) being held captive and forced to eat spaghetti against his will, its up to the heroes to fight—and have fun while they're at it.

With Jelly Jiggler somewhere in the park, the team searches A-Block while getting into all sorts of mischief: Bo-bobo rides a monkey train almost taken over by rabbits, Don Patch reunites with an old boyfriend that's now by-the-numbers, Gasser beats up more fish and Beauty watches a cat eat with utensils. And that's before a roller coaster rap about...turtles!?

While searching inside a haunted house, Gasser finds out he's getting married...to Bo-bobo!? And if that's not enough, he is also stuck fighting A-Block vice leader Katsu, who can counter abilities with smiley-face absorption! But with the hair-hunter's accessories collection incomplete and Bo-bobo fending off his own nose-hair fist, things take a turn for the strange...

Gasser's true power (and mental side effect) are finally revealed against Katsu, while the search for Jelly Jiggler comes to a weird climax as Bo-bobo finally faces off against the blue jelly man and his "Fist of the Wobble-Wobble". But when Bo-bobo should be fighting his greatest enemy, all he can do is eat him! (and worse off, without any ponzu sauce)

Bo-bobo and Don Patch's come together (literally) for a final assault on Jelly Jiggler! But after that...they decide to join the Hair Hunters!? While both are in the competition for the position, Bo-bobo's abilities in front of fans may put him at an advantage over bad seed Don Patch's ability to play a stick of butter. But the two of them don't know is that there are a couple of enemies keeping a close eye on them...

Bo-bobo encounters his greatest rival: Captain Battleship, the ducktailed master of a personal "Fist of the Nosehair" style! But there's more to him than meets the eye: how does Gasser know who he is? Why is he fighting against other Hair Hunters if he himself is a Hair Hunter elite? And what exactly does he want now outside running around as an octopus? All that we know is that this is the episode that teaches us that you can never have too many Beautys.

Our heroes finally reach Puppu City, Gasser's hometown and the current ruined home of Battleship's Pomade Ring headquarters (and where Beauty's being held hostage). But now they face an entire legion of problems, such as the Pomade Ring's army, a fish-loving second-in-command, floating heads, disgruntled businessmen, masked warriors who can't count, and of course...Serviceman. But take heart: if you have big sparkly eyes, you can fly away free from these problems!

With saving Beauty still on their mind, Bo-bobo and team prepare for one-on-one fights with The Battleship Five Quartet (who still number in six). Gasser fights first, having to go through a masked school filled with friends, enemies and sumo wrestlers until encountering an old ally turned rival. Then, Bo-bobo takes on a calendar who's afraid of losing all its pages...but it may not be the real enemy he should be worried about!

Bo-bobo, Don Patch and King Nosehair confuse the heck out of the second member of the Battleship Five Quartet, but after the results of that battle (and following battles by Don Patch and Jelly Jiggler), Softon sends Bo-bobo off to the mysterious World of Blabs-a-Lot to receive special training and get rid of his weakness. But even though he ends up running around with a bunch of chicken-headed tour guides and expelling fruit from yogurt, he ends up facing the mysterious last member of Battleship's masked warriors..and has just the attack to take care of him.

Back from his training trip (and after helping out in a carpentry lesson), Bo-bobo finally has his ultimate showdown with Captain Battleship, upon which the ducktailed warrior's sordid past and the truth of his hatred towards Bo-bobo is finally revealed! With bones flying, robots destroying and ultimate attacks from nosehairs to armadas to orange boxes showing up left and right, the two Fist of the Nosehair masters fight until one is finally standing at the end. But just when you think it's over...a new character appears at the end.!

Hatenko, a mysterious former ally of Bo-bobo from the Hair Kingdom, finally catches up with him to criticize his current status and stop anyone in his way. But that's before everyone learns of his obsessive devotion to his great "sun", Don Patch! And to make matters worse, along comes Kitty-Poo, the second of the Baldy-Bald Big Four to finish what Battleship started. (and to make fun of a certain shōnen anime classic) But there's one thing he forgot: never, ever underestimate Don Patch! And that's because Kitty-Poo and co-horts were each defeated by Don Patch by ONE attack!

Hatenko leads the group towards the Evil House of Blood, as if they were invited to a reception for Czar Baldy Bald's wedding. But instead, they're forced to go through several obstacles such as a returning Hair Hunt villain, allies turned into mind slaves, exploding cell phone assassins, brainwashed Bo-bobo soup, and the importance of wearing a fashionable raincoat. However, with doubts going through Gasser's mind about the key fighter's true purpose, all Don Patch wants is the power to win...as well as a much buffer body!

Bo-bobo and team finally arrives at Z-Block Base, from where the cute leader Dengaku Man has been taunting them for a while now. But to get to it, they must first get through a beachfront entrance with a powerful robot team who's just as good with beach volleyball as they are with asking for forgiveness! And once they make it inside the main headquarters, then they must go through a game show where the questions and contests get weirder by the second!

As their Z-Block trials continue, Bo-bobo and Don Patch decide to go into broadcasting...even if it means going inside a giant TV and facing off against a villain who can shine a light on them! But in the midst of all this, the horrific secret of Z-Block is revealed, Gasser and Beauty get stuck within a crowd of chefs and Bo-bobo dies after revealing himself to be a vampire! But that's before a strange black-haired Bo-bobo arrives with the power of fishcake and the ability to turn into a dragon...not to mention unleash yet another Z-Block warrior! Also, Beauty goes temporarily insane (on the level of Don Patch and Bo-BoBo