Dr. Kenzo Tenma, a leading neurosurgeon at the Dusseldorf Hospital has received massive acclaim for his successful surgery on a famous opera singer. However, he is burdened by guilt. Due to pressure from the director, he had operated on the opera singer on the night that he was supposed to operate on another man. As a result, when the director’s orders him to operate on the mayor, he decides to ignore the order and instead works on saving the life of a young boy, brought to the hospital from the scene of a serial homicide. However, the boy's twin sister, who was brought in with the boy, and who still suffers from shock, keeps repeating the words 'kill him'.

The price for disobeying Dr. Heinemann's orders to operate on the mayor is costly for Dr. Tenma. His career begins to plummet. The boy whom he saved finally awakens, but a horrible incident occurs soon after.

Things look brighter for Dr. Tenma, now that Dr. Heinemann is dead. His career takes off, and even Eva tries to win him back. But unfortunately, all that success has drawn the attention of Detective Lunge.

Adolf Junkers has information about the serial murders that is vital to the police, but he is afraid to reveal them. Dr. Tenma's care for Adolf Junkers however wins him over. His close relationship with Junkers however leads him to a night of shocking horror.

Nina Fortner, a talented young student in Heidelberg has been having nightmares. She also cannot remember anything about her life before she was 10 years old. She soon suffers from fainting spells in university and starts receiving anonymous emails.

Nina finally receives an email informing her to meet the anonymous sender at a specified time and place. Dr. Tenma in his search for the Liebert girl, asks Mauler, an editor for a local publisher, for assistance in his investigations.

Tenma and Nina return to the Fortners’ residence to find Mauler and Nina’s parents dead. Two detectives arrive to take them to the station for questioning, but certain things don't look right.

Eva tries to threaten Dr. Tenma, unless he gets back with her, she would reveal to the police that the tie that was found at the scene of the crime is his!

An old mercenary soldier named Hugo is interrogated by Lunge about a student of his, a doctor named Tenma.

Tenma encounters a burglar named Heckel who claims to have seen the killer. It soon results in Heckel leading Tenma to a couple of murderers.

Tenma learns that Johan used to be in an orphanage known as Kinderheim 511. And he meets a former East German official named Hartmann who used to work there and an injured boy named Dieter.

Dieter is picked up by Hartmann before Tenma could return. And Tenma learns more about the experiments in Kinderheim 511.

In a small village, Dr. Schumann worries over the health of his sick but stubborn old friend, Petra.

Inspector Lunge investigates the murder of a prostitute and suspects a senator named Dr. Boltzmann of involvement. His dedication to his work however takes a toll on his family life. Meanwhile, the vindictive Eva continues to press Lunge to catch Tenma. She also has a new lover, her gardener.

Dr. Tenma and Nina Fortner's investigations lead them to a powerful man known as 'The Baby', who belongs in an extremist organisation. They soon learn that the organisation has special plans for the Turkish district tomorrow.

Nina escapes the mansion. And Tenma meets with the unrecognizable General Wolf at the mansion later.

The extremists plans are put into action, and Tenma decides to postpone his search for Johan and instead heads to the Turkish district to warn the people there. Dieter and Heckel are captured by the skinheads and are left to burn in the fire. And Nina tries to get information about the 'main dish' from 'The Baby'.

Nina meets with an old friend and boss, Mister Rosso. The delightful old boss however, has a very dark past.

Tenma visits Rudy, a criminal psychologist, who is working on cases involving a murderer named Jurgens.

Tenma and Dieter hitch a ride with an elderly couple on the way to Freiham. Tenma wonders if the couple plan to turn him in.

Nina confronts Muller, one of the two detectives responsible for the death of her foster parents, the Fortners. Muller discovers that his protege, Roberto, is actually working for Johan and is now tasked with killing Nina.

Lunge determines that the murder of a wealthy, middle-aged, childless couple does not fit the usual modus operandi of the serial murders and decides to use this opportunity to lure Tenma to a trap. However, before he can arrest him, Lunge is critically wounded by the real criminal. Tenma is able to treat Lunge's injuries.

Eva Heinemann is arrested for public drunkenness and hooks up with Roberto, with whom she was with the night before her arrest. Roberto then reveals his link to Johan and Eva confesses that she was actually a witness the night Junkers was killed by Johan.

In exchange for her life, Roberto tells Eva to confront Tenma, who is currently treating a mob boss at a country house. Eva is promptly wounded by Roberto when she is unable to complete her task but is saved by Tenma.

Karl Neumann and Lotte Frank are both students who read latin to Hans Georg Schubert. Lotte attempts to assist Karl in finding out his past while trying to figure out the identity of a boy who reads to Schubert on Thursdays. When they both discover who he is, they find the boy, Edmund Farren, in his dormitory, dead.