When Chief of Internal Medicine Dr. Amy Larsen suffers a catastrophic brain injury, her life is turned upside down. Still determined to once again practice medicine, she charts a new path forward, ready to face whatever obstacles stand in her way.

While at the hospital recovering, Amy can’t help but insert herself into her roommate’s case. Meanwhile, all the other doctors and nurses have to adjust to the once formidable Chief now being the patient.

Amy, allowed to return to work under strict guidelines, teams up with TJ to treat a patient suffering from mysterious liver problems. Sonya and Jake help an elderly couple navigate the final chapter of their love story.

Amy must confront who she has become after the tragedy that struck her family seven years ago. Sonya and TJ disagree on how to treat a sick Marine, and Amy and Jake make a life-changing discovery about an Alzheimer’s patient.

Amy and Sonya endeavor to help a teen in need of a bone marrow transplant and his younger brother whose own health issues jeopardize his disability to donate. Jake deals with a fainting bride and her worried groom. Michael struggles with a secret he’s been keeping.

It’s a race against time as Amy and Jake try to uncover the cause of a unique patient’s worsening condition. Gina treats a quirky hypochondriac, and Amy makes a shocking discovery about her pre-accident love life.

Sonya wrestles with treating a guy from her past and must rely on Amy to help her. Richard (Scott Wolf) deals with a family situation. Jake and TJ debate the moral implications of a diagnosis.

Amy and Richard reconnect while treating a patient whose diagnosis is not at all what it seems. A real life romcom comes to Westside Hospital, bringing love to the forefront of everyone's mind.